Pressurized Liquid (PLE) Truffle Extracts Have Inhibitory Activity on Key Enzymes Related to Type 2 Diabetes (α-Glucosidase and α-Amylase)

An optimized PLE method was applied to several truffle species using three different solvent mixtures obtain bioactive enriched fractions. The pressurized water extracts contained mainly (1 → 3),(1 6)-β-D-glucans, chitins, and heteropolymers with galactose mannose in their structures. ethanol included fatty acids fungal sterols others such as brassicasterol stigmasterol, depending on the species. They also showed a acid lipid profile utilized considered. Ethanol:water interesting lipids many phenolic compounds; however, no synergic extraction of compounds noticed. Some were able inhibit enzymes related type 2 diabetes; inhibited α-amylase enzyme, while ethanolic more α-glucosidase. Tuber brumale var. moschatum T. aestivum uncinatum an IC50 29.22 mg/mL towards 7.93 Thus, use allows o fractions be obtained from truffles antidiabetic properties.